Umbilical Cord–Derived MSCs: Therapeutic Potential
Location: (India)
Umbilical Cord–Derived Mesenchymal Stem Cells (UC-MSCs) possess immense regenerative capability of regeneration. They act as an attractive source of stem cells due to their high proliferative capacity, potential in multilineage (differentiate into various cell types), and immunomodulatory properties. Historically, UC-MSCs were isolated from Wharton’s jelly. Moreover, UC-MSCs exhibit lower immunogenicity in comparison with adult tissue–derived MSCs. Thus, both are suitable for both autologous and allogeneic applications. The therapeutic effect of these cells is mediated via paracrine signaling that includes the release of growth factors, cytokines, and extracellular vesicles. The secretion of these molecules supports tissue repair, angiogenesis, and inflammation regulation. Various critical disease treatments can potentially use UC-MSCs, including neurological, inflammatory, and degenerative disorders.
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